Wednesday, June 10, 2009

Breast Cancer - Causes, Symptoms and Treatment (Breast Cancer)

Breast Cancer

Breast cancer is a malignant (cancerous) growth that begins in the tissues of the breast. Over the course of a lifetime, one in eight women will be diagnosed with breast cancer. Breast cancer is a cancer of the breast tissue, which can occur in both women and men. Breast cancer may be one of the oldest known forms of cancer tumors in humans.Worldwide, breast cancer is the fifth most common cause of cancer death (after lung cancer, stomach cancer, liver cancer, and colon cancer). Breast cancer kills more women in the United States than any cancer except lung cancer. Today, breast cancer, like other forms of cancer, is considered to be a result of damage to DNA. How this mechanism may occur comes from several known or hypothesized factors (such as exposure to ionizing radiation, or viral mutagenesis). Some factors lead to an increased rate of mutation (exposure to estrogens) and decreased repair (the BRCA1, BRCA2 and p53) genes. Alcohol generally appears to increase the risk of breast cancer.

Breast cancer can also occur in men, although it rarely does. Experts predict 178,000 women and 2,000 men will develop breast cancer in the United States. There are several different types of breast cancer. First is Ductal carcinoma begins in the cells lining the ducts that bring milk to the nipple and accounts for more than 75% of breast cancer. Second is Lobular carcinoma begins in the milk-secreting glands of the breast but is otherwise fairly similar in its behavior to ductal carcinoma. Other varieties of breast cancer can arise from the skin, fat, connective tissues, and other cells present in the breast. Some women have what is known as HER2-positive breast cancer. HER2, short for human epidermal growth factor receptor-2, is a gene that helps control cell growth, division, and repair. When cells have too many copies of this gene, cell growth speeds up.

Causes of Breast Cancer

Simply being a woman is the main risk for breast cancer. While men can also get the disease, it is about 100 times more common in women than in men. The chance of getting breast cancer goes up as a woman gets older. Nearly 8 out of 10 breast cancer are found in women age 50 or older. About 5% to 10% of breast cancer are linked to changes (mutations) in certain genes. The most common gene changes are those of the BRCA1 and BRCA2 genes. Breast cancer risk is higher among women whose close blood relatives have this disease. The relatives can be from either the mother’s or father’s side of the family. Woman with cancer in one breast has a greater chance of getting a new cancer in the other breast or in another part of the same breast. This is different from the first cancer coming back Many experts now believe that the main reason for this is because they have faster growing tumors. Asian, Hispanic, and American Indian women have a lower risk of getting breast cancer. Certain types of abnormal biopsy results can be linked to a slightly higher risk of breast cancer.Women who have had radiation treatment to the chest area (as treatment for another cancer) earlier in life have a greatly increased risk of breast cancer

Some pregnant women were given the drug DES (diethylstilbestrol) because it was thought to lower their chances of losing the baby. Recent studies have shown that these women (and their daughters who were exposed to DES while in the uterus), have a slightly increased risk of getting breast cancer. Use of alcohol is clearly linked to a slightly increased risk of getting breast cancer. Women who have 1 drink a day have a very small increased risk. Those who have 2 to 5 drinks daily have about 1½ times the risk of women who drink no alcohol. The American Cancer Society suggests limiting the amount you drink.Being overweight is linked to a higher risk of breast cancer, especially for women after change of life and if the weight gain took place during adulthood. Also, the risk seems to be higher if the extra fat is in the waist area. Breast-feeding and pregnancy: Some studies have shown that breast-feeding slightly lowers breast cancer risk, especially if the breast-feeding lasts 1½ to 2 years. This could be because breast-feeding lowers a woman’s total number of menstrual periods, as does pregnancy. Women who began having periods early (before 12 years of age) or who went through the change of life (menopause) after the age of 55 have a slightly increased risk of breast cancer.

Symptoms of Breast Cancer


1.Lumps.

2.Rash.

3.Breast Pain.

4.Cysts.

5.Nipple Discharge.

6.Inverted Nipple.

Treatment of Breast Cancer


1.Hormonal therapy (with tamoxifen).

2.Chemotherapy.

3.Radiotherapy.

4.Surgery.


By: Sushma Jain


Breast Cancer

Breast Cancer Risk Factors (Breast Cancer)

Breast Cancer

Anything that may increase the chance of developing a disease is considered a risk factor. As research has indicated women with certain risk factors are more likely than others to develop breast cancer.

The exact causes for breast cancer are not known. Often doctors cannot explain why one woman may develop breast cancer but another does not. What is known is that bruising, bumping or touching the breast does not cause cancer. Breast cancer is not contagious. It is not “caught” from others.

There have been studies that have revealed some of the risk factors for breast cancer. Among those risk factors are a woman’s age, a family or personal history of breast cancer, changes in her breast, changes in her genes and her menstrual history. Other risk factors for breast cancer include a woman’s race, if she has had radiation therapy to the chest, and her breast density. Still other factors for breast cancer include taking diethylstilbestrol (DES), her being overweight or obese after menopause, not being physically active, and her alcohol consumption.

Breast cancer is not common in women before menopause. As women age their chances for breast cancer development can increase. Breast cancer occurrence is greater for women over age 60.

The chance of a woman developing breast cancer is greater if her mother, sister or daughter has a history of the disease. If a family member developed breast cancer before the age of 40, the risk is even greater for a woman developing breast cancer. Other relatives having breast cancer, either on her maternal or paternal side of the family, can also place a woman at greater risk for developing breast cancer.

Having a personal history of breast cancer can also increase a woman’s risk. If a woman has had breast cancer in one breast the risk of getting breast cancer in the other breast increase.

Changes in a woman’s breast can place a woman at risk for breast cancer. Cells in a woman’s breast may look abnormal under a microscope. Abnormal cells such as atypical hyperplasia and lobular carcinoma in situ (or LCIS) increase a woman’s risk for breast cancer.

Changes in a woman’s genes including BRCA1, BRCA2, and others may increase the risk for breast cancer. Tests from family members who have been known to have breast cancer can reveal the presence of specific gene changes in family members. In order to improve the detection of this disease in women who have these changes in their genes health care providers may be able to suggest ways to try to reduce the risk of breast cancer.

A woman’s menstrual and reproductive history can place a woman at risk for breast cancer. Women having their first menstrual period before age 12 have a greater risk for developing breast cancer. The risk of breast cancer increase the older a woman is when she had her first child. A woman going through menopause after age 55 places her at greater risk for breast cancer. If a woman has never had children she is at a greater risk of breast cancer. Taking menopausal hormone therapy with estrogen plus progestin after menopause appears to increase risks for breast cancer. Studies have shown no link between miscarriage or abortion and risks for breast cancer.

Race is another risk factor for breast cancer. Caucasian women more often than Latina, African or Asian American women are diagnosed with breast cancer.

Radiation therapy performed to the chest, including the breast, before a woman is age 30 is another known risk factor for breast cancer. Studies indicate the younger the age of a woman when she received radiation treatment the higher the risk for breast cancer in later life.

A woman’s breast tissue is either fatty or dense. Placing them at a higher risk of breast cancer are older women whose mammograms, or breast x-rays, reveal more dense tissue.

Diethylstilbestrol, also known as DES, was given to some pregnant women in the United States during the 1940’s until 1971. This is no longer given to pregnant women. Taking DES during pregnancy may slightly increase the risk for breast cancer. The possible effects on the daughters of women who were given DES while pregnant are still being studied.

A woman being overweight or obese after menopause can increase a woman’s risk for developing breast cancer. Studies have indicated that after menopause the risk increases for women who are overweight.

A physically inactive lifestyle may contribute to risks for breast cancer. If a woman is active it can prevent weight gain and obesity and therefore reduce chances for breast cancer.

Drinking alcohol increases risks for breast cancer. Studies indicate the more alcohol a woman drinks her risk for breast cancer increase.

Researchers are currently studying other possible risk factors for breast cancer. Currently being studied are the effect of diet, genetics, physical activity, and certain environmental substances increasing the risks for breast cancer.

Avoiding known risk factors for breast cancer can help women protect themselves against breast cancer. Risk factors for breast cancer such as family history cannot be avoided. These should be discussed with her doctor.

Most women who have known risk factors do not get breast cancer. Many women with breast cancer do not have a family history of the disease. Most women with breast cancer have no clear sign for risk factors other than growing older.

If a woman thinks she is at risk for breast cancer she should discuss her concern with her doctor. Her doctor may be able to suggest ways she can reduce her risk. At risk or not, a woman should plan scheduled checkups with her health care provider. Prevention is the best cure.
By: John Marston


Breast Cancer

What Are The Risk Factors for Breast Cancer? (Breast Cancer)

Breast Cancer

Breast cancer is a largely unknown disease until today, despite the fact that it affects almost ten percent of the women above the age of forty years all over the world. The causes of this killer cancer are not known even after decades of research into it. Similarly it is unknown why some women have higher chances of getting breast cancer than others.

Though the causative factors are not known, some risk factors have been identified. There is no medical proof why these factors make the disease more probable, but this is a study of observation. In a vast cross-section of women with the observed risk factors, it has been found that the chances of getting breast cancer are very high.

The various risk factors for breast cancer are as follows:-

(1) Family History of Breast Cancer

If a near relative like a mother or a sister has had breast cancer, then there is a very high chance that the cancer will occur sometime in life. This propensity is observed even if far relatives such as cousins and aunts have had breast cancer, though the chances are lesser as the relatives are more removed. Even if a male relative has had breast cancer or prostate cancer, then there is a chance of getting breast cancer. This clearly indicates that breast cancer runs through family lines through inheritance. Certainly the chances are very high if more than one family member has had breast cancer.

(2) Personal History of Breast Cancer

If a woman has had breast cancer in the past, then there is a great chance that the breast cancer may recur. This is true even if the cancer had been removed in its benign stage itself. Sometimes the cancer cells spread into the nearby lymph. This makes a possibility that the cancer will occur in the opposite breast. In fact, women who have had cancer in one breast have 50 to 75% more chances of developing the cancer in the other breast.

(3) Diseases of the Breast

Several breast diseases can increase the chances of having breast cancer. Changes in the cells of the breasts can lead to atypical hyperplasia. This condition can cause a three to fourfold increase in the possibility of getting breast cancer in the later years. This risk also exists if the atypical hyperplasia has occurred in other women of the family. Another such condition is the benign breast tumor condition known as fibro adenoma. However, women with fibrocystic breasts generally do not have any added vulnerability to breast cancer. Yet, such conditions could make the breasts lumpy and hide the real tumors (if any) during mammography.

(4) Lifestyle

In today’s world, lifestyle is the single largest contributing factor for the proliferation of breast cancer among women. Several elements of the lifestyle have been found to be directly accordant with the prevalence of breast cancer. Smoking and alcoholism in women are among the chief factors. Even diet has been pointed out as an important risk factor. Women who consume a diet with more high-cholesterol fats in them have higher chances of breast cancer. At the same time leading a sedentary lifestyle without indulging much in physical activity are also potentially dangerous.

(5) Radiation

It has been found that women who undergo radiation therapies in their chest region at a young age have an increased risk of developing breast cancer in their later lives. Radiation therapy is generally prescribed for women with conditions like Hodgkin’s disease or non-Hodgkin’s lymphoma. So women who have undergone such treatments may get breast cancer in their later years.

(6) Hormonal Imbalances There are several factors that can change the hormone balance of the body. Some of them are:- a) Beginning the menstrual cycle early, i.e. before the age of twelve years, b) Having the first pregnancy after the age of thirty years, c) Having no pregnancy at all, d) Having a late menopause. All these conditions can increase the level of estrogen in the body. This increases the risk of getting breast cancer to a mild extent. Apart from that women who take regular birth control pills, breast enhancement supplements, antidepressants and antihistamines and hormone modifying supplements stand at a higher risk to get breast cancer.

The above are the major risk factors for breast cancer. But since the study on breast cancer is not yet complete, the above is by no means a complete list. There are several other indications of breast cancer, like breast implant operations; but these have not yet been confirmed. The implants used in the earlier days were made of silicone gels. These were riskier in terms of breast cancer. However, nowadays the silicone gel implants have been replaced by saline implants. This has reduced the risk to a great extent.

It must be also noted that women have much higher chances of getting breast cancer than men. In fact, most people think that breast cancer is a disease that affects only women. This is not true. Men also get breast cancer, but to a much lesser degree than women. Also, age is a very important factor. The chances of getting breast cancer are much higher when the woman has crossed the age of 50 years.
By: Anna Hardy


Breast Cancer

How To Tackle Breast Cancer Successfully? (Breast Cancer)

Breast Cancer

Breast cancer could very well be placed at number one among all the killer diseases in women today. This type of cancer accounts for 26% of all the cancers in women. As such, it is largest killer cancer of all people in world, except maybe lung cancer. With so many women becoming victims of breast cancer each year, it should be thought that the medical fraternity must be having very detailed information about it. But that is hardly the case. Despite the millions of women dying each year, the causes, mechanisms and treatment of breast cancer still remains shrouded in mystery.

A simple layperson's definition of breast cancer is that it is an abnormal growth of a mass of cells known as a tumor anywhere within the breast. This growth is felt as a lumpy mass in the early stages of the cancer. This is when the woman must rush to the doctor. In fact any sudden inexplicable abnormality in the shape of the breast must be given medical attention immediately. There is no cause for alarm, as most changes could be perfectly harmless. But it is wise to rule out the possibility of blood cancer.

Another aspect of urgent medical attention is that breast cancer is fully treatable if it is seen to early. In all women suffering from breast cancer, the tumor will undergo an initial benign stage. At this stage the tumor has not started its abnormal multiplication. If it is removed when it is benign, the cancer does not spread, and in most cases, the woman gets totally cured of the disease and leads a normal life.

Nothing can be said about how long the tumor will remain benign. That depends on several inherent factors with the woman's physiology. The period of benign tumor is another part of breast cancer about which very little is known. But the presence of a tumor or such other symptoms is a strong indicator of occurrence of breast cancer. Apart from the tumor, there could be changes in the coloration of the skin over the breast. Other skin changes such as crimpling and folding could occur. The symptoms of breast cancer are also observed over the nipple and the areolas. The nipples could become inverted without reason, or there could be deformities in their shapes. The same could occur at the areolas, which are the dark circles around the nipples. In the later stages of the breast cancer, there could be a discharge of fluids from the nipples. This discharge could be pus-like, or it could even be a discharge of blood.

Even though the exact causes of breast cancer are not known, there are some women who are termed by the medical facilities as high-risk groups for the disease. Topping this list are the women who smoke and consume alcohol on a regular basis. Women who are obese due to lack of exercise or a physiological problem come next. Breast augmentation surgeries such as breast implants were once considered to be a primary reason for breast cancer. This was in the days silicone gel was used as the implanting material. However, today with the replacement of silicone gel with saline gel, the incidences of women getting cancer due to implants has become drastically less. It is also found that breast cancer cases run in families. Hence if a close relative has breast cancer, there is a great chance that the other women in the family could get it too. This indicates a hereditary factor influencing breast cancer.

Though the causes of breast cancer are unknown, there is a proliferation of the amount of literature about its prevention. Most of these methods are just hogwash, but there are many precautionary points that women must consider. Women must give high priority to losing their body weight, especially if there has been a case of breast cancer in the family. It is also a good idea to have a regular checkup. The checkup could also be done at home with finger pressure. With two fingers, the entire breast must be gradually touched, poking at points to check if there is any undue hardness felt.

Some women take drugs that contain estrogen in them. These could be for almost about anything - from increasing the sexual drive to increasing the amount of milk during lactation. But it must be remembered that any kind of hormonal disarray in the body could only make matters worse. It is not yet proven, but it can be assumed that an increase in the amount of estrogen in the blood could hasten the chances of blood cancer.

There are some foods that have been identified by dieticians to be good for preventing breast cancer. These include cabbage, cauliflower, broccoli and legumes. Even oranges, tomatoes and other citrus fruits could have some effects. Soy and its products are also good. A low carbohydrate diet is suggested. At the same time, it is needless to say that the woman must abstain from smoking and alcoholism.

Indulging in regular exercise and maintaining an overall positive outlook towards life could be important to remain away from breast cancer. Some alternative therapists believe that mental tensions could be one of the causes of breast cancer.
By: Anna Hardy

Breast Cancer